Skip to main page content home current issue archive feedback subscriptions alerts help keywords go advanced â» user name password sign in effects of adrenalectomy and chemical sympathectomy on pressor and tachycardic responses to diphenyleneiodonium. Y x wang and c c pang department of pharmacology & therapeutics, faculty of medicine, university of british columbia, vancouver, canada. Abstract we have reported that diphenyleneiodonium (dpi), a flavoprotein inhibitor, caused pressor and tachycardic responses by indirectly activating the sympathetic nervous system. buy viagra In this study, bilateral adrenalectomy and chemical sympathectomy by 6-hydroxydopamine (6-oh-da) were used to examine the contributions of the adrenal medullae and sympathetic nerve terminals to the pressor and tachycardic responses to dpi in pentobarbital-anesthetized rats. viagra ingredients wiki Intravenous bolus injections of dpi (0. 05-1. 6 mg/kg) caused dose-dependent increases in mean arterial pressure and hr. viagra for cheap Neither bilateral adrenalectomy nor pretreatment (26 hr earlier) with 6-oh-da (100 mg/kg, i. P. ) significantly affected the dose-map curve of dpi, although 6-oh-da but not adrenalectomy slightly and significantly shifted the dose-hr curve to the right without affecting the maximum. point bathtubs viagra commercial The combination of bilateral adrenalectomy and 6-oh-da reduced the maximum mean arterial pressure and hr responses to dpi by 71% and 35%, respectively. viagra 20 mg long Intravenous bolus injection of dpi (1. 6 mg/kg) caused increases in plasma norepinephrine, epinephrine and dopamine of more than 2, 2 and 0. viagra cost 1 ng/ml, respectively. viagra coupon Although bilateral adrenalectomy reduced the dpi-induced increases of norepinephrine, epinephrine and dopamine by 85%, 100% and 93%, and 6-oh-da reduced these increases by 67%, 48% and 61%, respectively, the combination of adrenalectomy and 6-oh-da abolished the increases in catecholamines. should viagra covered health insurance These results show that sympathetic nerve terminals and sympathoadrenals play overlapping roles in the pressor and tachycardic responses to dpi, with the adrenal medullae as the primary source of plasma catecholamines released by dpi. viagra without prescription â« previous | next article â» table of contents this article jpet may 1994 vol. 269 no. 2 463-469 â» abstract full text (pdf) services email this article to a colleague alert me when this article is cited alert me if a correction is posted alert me when eletters are published similar articles in this journal similar articles in pubmed download to citation manager responses submit a response no responses published citing articles load citing article information c. generic viagra mexico pharmacy buy viagra canada


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